I. Ideal for:
- Patients with impaired mitochondrial functions (ageing/disease), statin users, elderly, athletes, and those seeking reproductive support.
- Ingredients per Softgel:.
- Ubidecarenone (Coenzyme Q10): 150 mg
- Sacha Inchi Seed Oil: 600 mg
- Vitamin K2: 105 mcg
- Vitamin E (Alpha-Tocopherol): 50 IU
- Panax Ginseng Root Extract: 25 mg
- Olive Oil: 167 mg.
II. Lipid Delivery Matrix
Coenzyme Q10 is naturally water-insoluble and lipophilic, leading to poor bioavailability in standard powder formulations. Q utilises a Lipid Delivery Matrix to overcome this barrier.
The Process:
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Solubilisation: CoQ10 is dissolved within a high-concentration matrix of Sacha Inchi and Olive oils.
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Micellization: Upon ingestion, these functional lipids facilitate the formation of micelles in the gastrointestinal tract.
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Enhanced Absorption: These micelles act as a strategic vehicle, allowing lipophilic nutrients to be easily absorbed by the intestinal lining for systemic distribution.
III. Mechanism of Action
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Mitochondrial Bioenergetics and Biogenesis: CoQ10 is an essential electron carrier in the mitochondrial electron transport chain (ETC) for ATP production. Panax Ginseng (ginsenosides) has been strategically titrated to 25 mg to promote mitochondrial biogenesis (increasing mitochondrial number and efficiency), synergistically boosting CoQ10 and Vitamin K2 function without the side effects (insomnia/hypertension) of higher doses.
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Metabolic & ACE Regulation: SIO contains ALA, which activates PPARγ for insulin sensitisation and increases Sirtuin-1 (SIRT1) expression to stimulate glucose-dependent insulin secretion. Additionally, lower molecular weight peptides in Sacha Inchi extract exhibit Angiotensin-I converting enzyme (ACE) inhibitory activity.
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Vascular & Bone Homeostasis: Vitamin K2 (MK-7) activates Matrix Gla Protein (MGP) to inhibit vascular calcification and Osteocalcin to direct calcium into the bone matrix.
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Neuroprotection: SIO improves GABAergic transmission, balancing brain signals, while CoQ10 protects synapses from amyloid-beta (Aβ) neurotoxicity.
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Immunomodulation & Skin Health: SIO increases the activation potential of T- and B-cells. Dermatologically, it improves skin moisture content and prevents Staphylococcus aureus attachment to keratinocytes.
IV. Indications & Evidence
- Hypertension & Dyslipidaemia: A 2025 human trial (1000 mg/day SIO) showed significant reductions in systolic BP (-8.6 mmHg) and diastolic BP (-7.0 mmHg), reduced total cholesterol (-0.6 mmol/L) and LDL-C (-0.3 mmol/L), and improved HDL-C levels.
- Arterial Stiffness: MK-7 supplementation significantly reduces pulse wave velocity (PWV), improving arterial elasticity by activating MGP.
- Statin Support: Statins block the mevalonate pathway, depleting endogenous CoQ10. Trials confirm CoQ10 effectively reduces fatigue and statin-induced myopathic symptoms.
- Fatigue Reduction: A 2022 meta-analysis of 13 RCTs confirmed CoQ10 significantly reduces fatigue symptoms (Hedges’ g = -0.398), with a dose-response relationship.
- Reproductive Health: Pretreatment significantly increased clinical pregnancy rates (OR = 1.84) in women with diminished ovarian reserve and improved sperm concentration/motility in men after 6 months.
V. Administration & Safety Notes
- Dosing: 1 softgel daily, optimally taken in the morning.
- Enhanced Absorption: Biting the softgel prior to swallowing provides a more immediate energy response via rapid mucosal contact of the lipid-solubilised nutrients.
- Anticoagulant Therapy (Warfarin): Vitamin K vitamers are antagonists to Vitamin K Antagonists (VKAs) like warfarin. Patients on VKAs must be monitored closely, as Vitamin K can reduce medication efficacy.
- Form Stability: ROVITAC-Q uses Ubiquinone because research indicates 76% to 84% of oral ubiquinol is oxidized back to ubiquinone in the small intestinal environment before absorption.
- Upper Safety Limits: CoQ10 is documented safe up to 1,200 mg/day and does not inhibit endogenous biosynthesis.
FAQ
- Q: Can it be given to pregnant women? 1 softgel daily, optimally taken in the morning
- A: Clinical evidence indicates CoQ10 pretreatment reduces miscarriage rates (OR = 0.38). While safe, pregnant women should consult their attending OB-GYN to ensure it aligns with their prenatal plan.
- Q: Why choose MK-7 over Vitamin K1?
- A: Vitamin K1 has a short half-life (1–2 hours). MK-7 has a long half-life (2–3 days), allowing it to remain in circulation longer and reach extra-hepatic tissues like bone and vessel walls more effectively.
- Q: Is the 25 mg Panax Ginseng dose effective?
- A: Yes. It is a "sweet spot" dose to enhance mitochondrial biogenesis and ATP production synergistically with CoQ10 without inducing hypertension or insomnia.
References
- Tsai I-C, et al. (2022). Frontiers in Pharmacology, 13:883251.
- Mhd Rodzi NAR, et al. (2025). Plant Foods for Human Nutrition, 80:80.
- Lin G, et al. (2024). Annals of Medicine, 56(1):2389469.
- Balercia G, et al. (2009). Fertility and Sterility, 91:1785–92.
- Hariri E, et al. (2021). Open Heart, 8:e001715.
- Fišar Z, Hroudová J. (2024). Antioxidants, 13:191.
- Mhd Rodzi NAR, Lee LK. (2022). Heliyon, 8:e10572.
- Judy WV. (2021). Integr Med (Encinitas), 20(6):24-28.
- Hiebert J, et al. (2012). The Internet Journal of Internal Medicine, 9(2).
- Møller ME. (2015). Agro Food Industry Hi Tech, July 2015.
- COA (Ref: 25-115262a). Besmed Medical Supplies, June 2025.
- Rovitac-Q Brochure. Besmed Medical Supplies.
